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Sản phẩm » Gastrointestinals
Sulfaguanidin
Dosage form: Tablet
Active Ingredient - Strength: Sulfaguanidine 500mg
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Thông tin chi tiết của sản phẩm

SULFAGUANIDINE Tablet

 
Active ingredient: Each tablet contents
Sulfaguanidine ………………….500mg
Indication
Susceptible infections.
Dosage
PO 6-12 g/day in 2 divided doses. Children: 100 mg/kg/day.
Contraindications
Porphyria; severe renal or hepatic failure; blood disorders; hypersensitivity to sulfonamides; SLE. Pregnancy (prior to delivery). Lactation. Infants within 1-2 mth of birth.
Special Precautions
Adequate fluid intake is necessary to reduce the risk of crystalluria. Discontinue immediately if rash appears. Renal or hepatic impairment; asthma or history of allergy; elderly. G6PD deficiency.
Adverse Drug Reactions
GI effects, hypersensitivity reactions, nephrotoxic reactions, hepatic disorders, CV effects, hypoglycaemia, hypothyroidism, neurological reactions. Pseudomembranous colitis; jaundice and kernicterus in the newborn.
Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylaxis, blood dyscrasias.
Drug Interactions
Action antagonised by PABA and procaine group of local anaesthetics. Potentiates oral anticoagulants, methotrexate and phenytoin. Increased risk of crystalluria with compounds that render urine acidic.
Mechanism of Action
Sulfaguanidine is a sulfonamide with properties similar to those of sulfamethoxazole. Sulfonamides have a similar structure to para-aminobenzoic acid (PABA) and interfere with the synthesis of nucleic acid in sensitive microorganisms by blocking the coversion of PABA to the co-enzyme dihydrofolic acid, a reduced form of folic acid. Their actions are primarily bacteriostatic, although bactericidal effects are exerted where concentrations of thymine are low in the surrounding medium.
A07AB03 - Sulfaguanidine; Belongs to the class of sulfonamide antiinfectives. Used for the treatment of intestinal infections.
Shelf life: 36 months
Presentation:
Box of 10 blisters x 10 tablets
 
For further information please contact us:
Manufacturer: Thanh Nam Pharmaceutical Production Trading Company Ltd.
Address: 60 – Doc Lap Avenue, Vietnam Singapore Industry Park
Thuan An, Bình Dương
Office: 3A Dang Tat Street, Tan Dinh ward, district 1
HCM city, Vietnam 
Telephone : (+84650) – 3767850           Fax : (+84650) – 3767852
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